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GLP-1R modulator C16 is a small-molecule allosteric modulator that enhances GLP-1 binding to the GLP-1 receptor via a transmembrane site (CAS 875005-43-9). It is characterized in vitro with an EC50 of 8.43 ± 3.82 μM, a molecular weight of 408.89 g·mol⁻1, and high chemical purity suitable for research applications.
Allosteric modulator of GLP-1 receptor activity.
Characterized potency (EC50 8.43 ± 3.82 μM) for in vitro studies.
High chemical purity (99.6%) for reproducible results.
Compact quantities suitable for early-stage pharmacology.
Useful for studying GLP-1R pharmacology and GPCR signaling.
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Sulindac(MK-231) is a non-steroidal COX inhibitor which potently inhibits prostaglandin synthesis used in the treatment of acute or chronic inflammatory conditions
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Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity. For research use only. MedChemExpress does not sell to patients.
Solubility in vitro: DMSO at 50 mg/mL (146.88 mM), requires ultrasonic assistance, use newly opened DMSO due to hygroscopic nature.
Stock solution storage: -80°C for 6 months; -20°C for 1 month.
Shipping: Room temperature in continental US; may vary elsewhere.
Storage of powder: -20°C for 3 years; in solvent: -80°C for 6 months, -20°C for 1 month.
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An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
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GPR120 modulator 1 is a G protein coupled receptor 120 (GPR120) modulator. This compound, extracted from patent US8394841B2 (compound example F1), is suitable for research into diseases linked to abnormal or deregulated GPR120, including diabetes.
Modulates G protein coupled receptor 120 (GPR120)
Supports research on diseases linked to GPR120 deregulation, such as diabetes
Purity of 98.1% (HPLC)
White to off-white solid appearance
Chemical formula C19H16ClNO4S
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Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. It promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. It protects the heart through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission and exhibits both anticancer and anti-inflammatory properties.
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GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM). This compound is for research use only.
Allosteric modulator
Enhances GLP-1 binding to GLP-1R
Via a transmembrane site
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Sodium decane-1-sulfonate is an anionic surfactant utilized for the analysis of organic small molecule compounds through HPLC and ion-pair liquid chromatography.
Anionic surfactant
Used for analysis of organic small molecule compounds
Suitable for HPLC
Suitable for ion-pair liquid chromatography
Biochemical assay reagent
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Sirtuin modulator 2 (Compound 132) is a sirtuin modulator exhibiting an ED50 equal to or less than 50 μM. It is intended for research use only. This compound is characterized by its molecular weight of 349.41 and appears as a light yellow to yellow solid.
Appears as a light yellow to yellow solid.
Has an ED50 equal to or less than 50 μM.
Intended for research applications.
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